The spread of STIs is a burden in developing countries and is majorly due to the failure to practice secure sexual relationships yet safe sex is highly required to be emphasized in order to regulate the associated health problems. The main objective The study focused on the determinants for the negotiation of safe sex among married women in Uganda aged 15-49 Methodology The study used secondary data from the UDHS (2016) women data set and the study sample was 5614 which considered married women in Uganda. Results Wealth index and education level had p-values less than 0.05 implying that they were significantly related to women’s negotiation for safe sex. Conclusion The findings indicated that most of the background characteristics were not statistically related to safe sex negotiation however education level and wealth index had a significant relationship. Negotiation of safe sex is highly hindered by women’s position in society and low levels of women empowerment, many women are not knowledgeable about their rights since most communities are male headed . Recommendations The government should put more effort in the sensitization of people regarding health issues and providing free and accessible health services such as treatment of STIs and free condom such that the risk of unsafe sex are regulated.

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