Introduction: Malaria is a parasitic infection caused by the 4 species of Plasmodium that infect humans: vivax, ovale, malariae, and falciparum. Of these, Plasmodium falciparum is the deadliest. The infection is transmitted by the female anopheles mosquito. Main purpose: To determine prevalence of malaria among pregnant mothers attending antenatal care at Nsangi health Centre III. Methodology: The research used a descriptive cross-sectional survey research design because it attempts to describe, explain and interpret current factors contributing to prevalence of malaria among pregnant mothers attending antenatal at Nsangi H/III located in Wakiso district. The study was carried out at Nsangi H/CIII located in Wakiso District and the surrounding areas. The study was carried out among pregnant mothers aged between 18-45 years attending Nsangi H/C III Wakiso district. Results: The ages were reported in years which are grouped into three categories of; (18-25), (26-35) years and (36 - 45) years. most of the respondents 40 (50.0%) were between 18 to 25 years. majority 55(68.7 %) of the mothers reported yes that there is malaria infection among pregnant mothers. Most of 30 (37.5 %) of the mothers had low INTs coverage and least of 8(10%) of pregnant mothers had Lack of reminder about INTs. Conclusion: The prevalence of malaria among pregnant women in Nsangi Health Centre III was high with 50 (62.5%). Most of the pregnant women were affected with malaria during the 3rd trimester. The prevalence of malaria was high in third trimester with 48 (57.5%) and lowest prevalence of malaria was observed in first trimester with 15 (18.7%). Majority 50 (62.5%) of the pregnant mothers reported malaria positive Recommendation: improving housing conditions, pregnant women should be encouraged to take fansidar for IPT. The DHO should place more effort to increase ownership and use of mosquito nets in Nsangi Health Centre III.

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