Introduction: safe male circumcision (SMC) remains a key intervention in reduction of sexually transmitted infections (STIs), Human Immune Virus (HIV) as well as reduction in penile cancer and cervical cancer among females of circumcised males. However, despite its intended benefits, uptake of the surgical procedure remains too low (10.8%) among males aged 30-45 years worldwide and worse still in Uganda. The study specifically sought to establish individual, socio-cultural and health facility factors affecting uptake of SMC as an HIV prevention strategy among male clients (30-45 years) attending Kasonga Health Centre III, Kikuube District. Methods: The study adopted a descriptive, cross-sectional design and employed a quantitative method of data collection among 30 conveniently sampled male clients aged 30-45 years who voluntarily consented to participate and filled the study questionnaire. Raw data was collected, analyzed and findings presented in tables and figures with corresponding statistical texts. Results: Individual factors like fears of erectile dysfunction and loss of libido (66.7%) were found to affect uptake of safe male circumcision among male clients aged 30-45 years. In absence of any socio-cultural factor, while in the health facility, preference of male surgeons to perform SMC (63.3%), not being provided with adequate information (70%), negative attitude of the SMC surgeons (80%), not being satisfied with overcrowding and lack of privacy in the SMC clinic (83.3%), not being provided with adequate drugs to facilitate wound healing (60%) and waiting more than 2 hours (46.7%) affected uptake of SMC among male clients. The study recommended that Health workers in the Hospital need to organize behavior change communication campaigns among males clients to improve uptake of safe male circumcision. This can be done through community based approaches such as schools, churches and markets.

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