Making right and informed choices is important in attaining organizational goals. Organizational supervisors are charged with the duty of formulating different strategies and plans to ensure smooth running and provision of latest and reliable data relating to organizational assets. This study sought to examine the influence of project management information system (PMIS) on the decision-making processes in an environment characterized by multiple projects within the healthcare sector of Kenya. Its purpose was to determine how the quality and quantity of PMIS information, project management, and PMIS information sharing in complex and multi-project environment influence decision-making processes. The study utilized a cross-sectional study design. The study population comprised of stakeholders who are the actual users of the Ministry of Health Project Management Information System DHIS2 (MoH PMIS DHIS2) platform and project leaders, including international development partners, division and departmental heads in the ministry of health, as well as county governments. A structured questionnaire was employed to gather data. The findings unmasked that the quality of information has a substantial and direct effect on the quality of decisions made. Quality information results in quality decisions. It was also found that the quantity of information, project management in complex environments, as well as PMIS information sharing directly and significantly affects the quality of decisions made. The study made the following recommendations: policymakers within the health sector need to encourage information exchange and sharing to help in better decision-making, project managers to secure quality project management information system while managing their projects, and the ministry of health need to ensure that the is sufficient and appropriate information in the PMIS to make better decisions within the industry.

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