Introduction: In Uganda where Nakapiripirit district is situated, malaria is highly endemic and its burden is persistently high accounting for 34% of outpatient visits and 28% of hospital admissions in the country. Almost all the age groups in Uganda are affected by the disease, but greatest focus in control is being pointed at pregnant women and the children under the age of 5 for these are said to be the most vulnerable. However, little concern is been shown regarding knowledge, attitudes and practices of residents regarding indoor residual spraying. This study therefore aims at assessing knowledge, attitudes and practices of households regarding indoor residual spraying in Kakomongole sub-county, Nakapiripirit district. Methods: This was a cross sectional study employing quantitative methods of data collection. Simple random sampling technique was used to collect data from 97 study respondents using semi structured questionnaires. Data was entered in epi-data and exported to stata version 14 for analysis. Results were presented in form of tables, bar graphs and pie charts. Results: Majority of the study respondents 55.7% (54/97) were female, 39.2% (38/97) were aged 26-30 years, 34.0% (33/97) were Catholics and 48.5% (47/97) were peasants. About 51.5% (50/97) reported to have heard about indoor residual spraying, 55.7% (54/97) had been sensitized about indoor residual spraying and 48.5% (47/97) reported that IRS benefited them. About 34.0% (33/97) strongly agreed that malaria is a serious disease, 40.2% (39/97) strongly agreed that IRS is effective in malaria control and 34.0% (33/97) strongly disagreed with the statement that it is useless to apply IRS because you can suffer from Malaria anyway. Furthermore, 70.1% (68/97) reported to have ever used indoor residual spraying and 51.5% (50/97) reported not to be currently using IRS. Conclusions: There were generally low levels of knowledge of study respondents regarding indoor residual spraying as only about half of the study respondents reported to have heard about IRS. The attitudes of study respondents were generally positive as majority strongly agreed that it is an effective intervention in addressing the public health burden of malaria. Regarding practices about use of indoor residual respraying, study respondents generally had good practices as over 70% reported to have utilized indoor residual spraying. However, the level of utilization was observed to be reducing as only half were still using at the time of the study.

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