The Quality of medical care in hospitals needs a lot of efforts to be improved; today these efforts are mainly focusing on increasing the practice of evidence-based medicine through the use of Clinical Decision Support System (CDSS). Proper use of clinical information is especially important in an effort to make sound clinical decisions and provide quality health services. The purpose of this project was to develop the Clinical Decision Support System (CDSS), A web application to be used by medical workers to assist them in carrying out evidence based clinical decisions in hospitals. This will be used by hospitals to assist them during all phases of clinical decision. The app will be accessed via a web browser with internet connection. Qualitative data collection techniques were used to gather information using questionnaires and interviews that were issued to a population sample size of 3 medical centers around central Kampala. The findings revealed that there is need for clinical decision support system in the hospitals. The findings also revealed the system requirements such patient data management and real-time diagnosis which are needed to develop the system. The output of this project is a fully functioning Clinical Decision Support System to be used by the medical workers online. Keywords: Web Application, Clinical Decision Support System, Medical workers, Clinical decision.

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