Uganda’s incidence rate of TB is 200 per 100,000 persons with 60% co – infected with HIV. This double pandemic situation increases the morbidity and mortality rates among HIV patients. The purpose of the study was to identify the factors contributing to spreading of tuberculosis among HIV positive clients at Kawolo general hospital, Buikwe district. The study used a cross section al descriptive design that employed quantitative data collection methods. The study enrolled 40 respondents who were selected using a simple random method. Data was corrected with use of both using an interview guide and checklist. Results were analysed and presented into tables, graphs and figures using Micro soft excel. The study results showed that individual factors were29 (62%) were underweight, 21(52.5%) consumed alcohol sometimes and 25(62.5%) had no history of TB. Among socio – economic factors, 25(62.5%) were unemployed, 19(47.5%) received emotional support and 27(67.5%) had family history of TB. HIV related factors were; 21(52.5%) were diagnosed with HIV for > 10 yet 23(57.5%) had took ART for 5 – 10 years and 26(65%) had viral load of 101,001 – 1,000,000 copies per ml. Conclusively, HIV related and socio – economic factors had a great influence on spreading of TB while individual factor had very minimal influence. Therefore, it is recommended that HIV patients should improve on their general care like adherence to ART and TB – prophylaxis so as to minimize spreading of TB infections.

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