A survey was conducted to assess the knowledge on the occurrence of PPR in small ruminants, plants used for medicine and health management practices for treatment of PPR in five disticts in Karamoja region. A total of 150 respondents (75 for the sheep interview and 75 for the goat interview) were interviewed in the districts of Nakapiripirit, Amudat, Nabilatuk, Moroto and Napak. Generally, more males were interviewed compared to the females and most of the informants were illiterate. There was a highly significant (P˂0.05) association between the informants who had ever heard about PPR and the informants who were aware about its occurrence in the five districts in Karamoja region. There was a highly significant (P˂0.05) association between the informants whose sheep and goats had ever suffered from PPR and they had used herbal remedies to treat the animals. Most plants which were used as medicine were obtained from the plant families of leguminosae, asteraceae and rutaceae. The herbal remedies were extracted from plant parts including; barks, leaves, roots, fruits and flowers. There were three main modes of preparation of medicine including; drying, grinding and pounding; adding water and boiling; pounding and soaking. The most dominant routes of administration of herbal remedies were the oral and topical routes. There was a highly significant (P˂0.05) association between the sheep and goats which had ever suffered from PPR and the effectiveness of herbal remedies in the treatment of PPR. Most informants used 2 teaspoons of herbal remedies for the young animals (kids and lambs) and 250 mls for the adult animals. Studies should be conducted on the use of herbal remedies using other routes of administration notably; intra-muscular and intravenous routes. Studies should be conducted on the use of other plant parts in the extraction of herbal remedies such as; flowers, fruits and plant latex. Furthermore, the studies on the use of herbal remedies should be conducted on the treatment of other major small ruminant diseases.

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