Introduction: Malaria infection during pregnancy has remained a major public health concern in tropical and subtropical countries with notable risk for the pregnant woman and her fetus. According to the estimated yearly report, the number of pregnant women who were at risk of malaria was about 25 million. It has been reported that in sub-Saharan Africa malaria can cause as many as 10,000 cases of malaria-related deaths in pregnancy per year, usually due to severe maternal anemia. More so, each year, malaria in pregnancy is responsible for 20% of stillbirths and 11% of all newborn deaths in sub-Saharan Africa. World Health Organization, (2018) Uganda is among the ten countries in sub-Saharan Africa that contribute to approximately 70% of global malaria cases and deaths. Uganda is a malaria endemic country with active transmission in 99% of the country. Whereas all people in Uganda are at risk of contracting malaria, children under-5 years of age and pregnant women are the most vulnerable group. MOH- Uganda malaria annual report, (July 2017- June 2018) Objectives: The main objective of this research was to determine the prevalence of malaria in pregnant women attending antenatal clinic at Nsinze Health Centre IV, Namutumba district. Methodology: The study design was cross sectional laboratory and descriptive and the objectives were to determine the prevalence of malaria in pregnant women and to identify the most prevalent species of plasmodium. Approximately 230 women were tested for malaria using both RDT and Microscopy from which the species of malaria parasite were identified and a drug susceptibility test of the plasmodium was carried out to determine the minimum inhibitory concentration of the parasite. The data was analysed by Statistical Package for Social Science (SPSS) and presented as graphs, tables and percentages. Consent was sought from the pregnant women before they participate in the study.

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