Introduction: In Uganda adolescents have an average of 1.8 sexual partners and only 54% use condomsdespite extensive voluntary counseling and testing strategies all over the country to prevent STIs (Renzaho, et al., 2017). This puts the youth at risk of getting sexually transmitted infections. Therefore a study on the level of knowledge, attitude and practices towards the prevention of sexually transmitted infections among the youths in Bidi Bidi Refugee Camp was carried out. Methods:A descriptive and cross sectional research design using qualitative method of data collection were used to carry out this study. A sample size of 420 respondents who were youth at Youth Centre was used. Data was collected using a face to face structured and semi structured interviews.And presented as a descriptive data using frequency tables and pie chart. Results: Respondents had moderate knowledge towards the prevention of STIs as all 420 (100%) had ever heard of prevention of STIs, 302 (79%) understood it as safe sexual intercourse and avoid body and blood contact, 267 (64%) knew HIV and gonorrhoea as the commonest STIs, 187 (61%) knew condoms as a preventive measure while 176 (42%) reported painful urination and itching as the major signs and symptoms of STIs.Respondents generally had negative attitude towards the prevention of STIs as290(69%) not freely seek STIs VCT services, 319 (76%) felt not at risk of STIs infection,345 (82%) marry any partner regardless of their sex history and 328 (78%) would not regularly use a condom. The practices towards prevention of STIs were generally poor as 265 (63%) were not married but 184 (47%) had two partners and more, 353 (84%) had been in more than one sexual relationship of recent, 322 (77%) had never used condoms, 298 (71%) had ever used drugs before and during sex intercourse. Majority 244 (58%) had never undergone STIs VCT services and 386 (92%) never first tested for STIs before sexual intercourse with new sexual partner. Conclusions and recommendations:In conclusion respondents had moderate knowledge about prevention of STIs but had negative attitude and poor practices towards STIs prevention. The study recommends that, youth are counselled about better ways of STIs prevention through behavioural change of regular condom use, being faithful and abstain from sex.

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