Background Diarrhea remains the leading cause of morbidity and mortality in children under 5 years old worldwide. The burden is disproportionately high among children in low- and middle-income countries. Young children are especially vulnerable to diarrheal disease and a high proportion of the deaths occur in the first 2 years of life. Objective The aim of the study was to access factors influencing diarrheal diseases among under-five children in Kanyanda, Luwero District Method A descriptive cross sectional study was employed to assess the factors influencing diarrheal diseases among under-five children in Kanyanda, Luwero District. A total of 279 care takers/mothers of children under-five years were included in this study using non probability, convenient sampling technique. A structured questionnaire was used to collect data. Data were enteredand analyzed using SPSS version 17. Results From the assessment done the prevalence of childhood diarrhea disease was high at 47.7%. age of the child (P=0.00), place where the child was born (P=0.044), duration of breastfeeding (P=0.00), immunization status (P=0.00), maternal age (P=0.00), number of children in the household (P=0.00), maternal education (P=0.00), maternal employment (P=0.02), type of toilets (P=0.00), adult defecation (P=0.00), presence of flies in the kitchen (P=0.00) and domestic animla near house (P=0.00) were independently associate with occurrence of childhood diarrhea. Conclusion The findings highlight the need for going educational, informational and improving on the socio-economic status, sanitation interventions of the respondents to address the factors of childhood diarrhea diseases in order to decrease the rate of childhood diseases among children below five years.

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