Background: Tuberculosis (TB) is the cause of 1, 8 million deaths annually, 99% of the deaths occurs in the developing countries and among the poorest people of these countries. Studies between high and low income countries demonstrate that rates of TB are significantly higher in poorer populations. World Health Organization introduced DOTS as global strategy for providing TB services which was expected to be delivered primarily by government run public health services (WHO, 2015). Objective: The main objective was to assess the factors influencing adherence to anti tuberculosis treatment among pulmonary tuberculosis patients attending Mpigi general hospital Method: A descriptive cross sectional study was conducted using qualitative method of data collection. 133 respondents were sampled using simple random sampling technique. Responded were interviewed with a structured standard questionnaire. 4- item Morisky Medication Adherence Score (MMAS)was used to measure adherence. Results: 36% of the study participants were found to be adherent to their prescribed medication Conclusion: High percentages of respondents were not adherent to their medication. Factors that influenced adherence were; Age, Marital status, occupation, level of education , Smoking, drinking alcohol, meals per day, knowledge about TB, Medication availability in the hospital, distance from the hospital and co morbidity.

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