Introduction: The topic of the study was Factors influencing uptake of safe medical male circumcision among male aged 18-38 years in Rweta village Pallisa district. Objective: Asses factors influencing the uptake of safe medical male circumcision among male aged 18-53years in Rweta village Pallisa district. Methodology: Crosses sectional study was done and correspondents conveniently selected questionnaires were used to obtain data. Results: client related factors found to influenced uptake of safe medical male circumcision (importance of male circumcision X2 71.578, p<0.001, would like to be circumcised X2 16.285, p<0.001, knew importance of safe medical male circumcision X2 52.187, p< 0.001, ever heard of medical circumcision (X2 7.925, p=0.005, ever heard of male circumcision reducing HIV infection X2 12.138, p<0.001 medical circumcision increases sexual feeling X2 32.114, p<0.001, fear of losing sexual time during recovery X2 18.984, p< 0.001, male circumcision is painful X2 43.675, p< 0.001) and only two health facility factors were found to influence uptake of safe medical male circumcision (welcoming health worker X2 7.644, p=0.006, and waiting time X2 9.479, p=0.002). The socio-demographic factors that influenced uptake of medical male circumcision (level of education X2 13.007, p=0.005, marital status X2 8.202, p=0.042, tribe X2 8.576, p= 0.036, religion X2 35.952, p <0.001, occupation X2 13.809, p 0.003). Conclusion: It was concluded that majorities of people knew the advantage of safe medical male circumcision informally and thus have fears in taking up medical male circumcision.

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