Introduction The study investigated the factors influencing shisha smoking among adults in Kabalagala, Makindye division. Objectives 1) To determine the shisha smoking status of adults in Kabalagala, Makindye division. 2) To determine the socio demographic factors influencing shisha smoking among adults in Kabalagala, Makindye division. 3) To identify the environmental factors influencing shisha smoking among the adults in Kabalagala, Makindye division .4) To identify the psychological factors influencing shisha smoking among the adults in Kabalagala, Makindye division. Methodology A cross sectional study design was carried out in Kabalagala on adults, both smokers and non smokers of shisha. Using self-administered questionnaires, a total of 250 respondents were sampled using convenience sampling technique. For uni-variate analysis, data was run using frequencies and percentages, and the results presented in form of frequency tables and pie-chart. At bi-variate level, Chi-square tests were used to show the levels of association between the dependent and independent variables through cross tabulations and results presented in tables. Results Of the 250 respondents, 103 (83.4%) practice shisha smoking and only 147 (16.6%) don’t smoke shisha. The socio demographic factors; marital status (X2 = 8.861, p = 0.031) and religion (X2 = 17.956, p <0.001) were associated to the shisha smoking among adults. The environmental factors; cost(X2=52.518, p<0.001), availability(X2=4.029, p=0.045) peer pressure(X2=16.022, p=0.03) and parent smoking status(X2=0.09, p=0.03) were associated to the shisha smoking practice. The psychological factors: history of loss friend/relative(X2=4.023, p=0.045) and history of stress(X2=66.260, p<0.001); were also associated to the shisha smoking practice among adults. Conclusion and Recommendation Socio demographic factors; knowledge, perception, marital status and religion. Environmental; peer pressure, cost and availability are the major factors influencing shisha smoking in Kabalagala, Makindye division psychological factors:loss of friend/relative and history of stress are the major factors influencing shisha smoking in Kabalagala,Makindye division. The researcher recommends the Ministry of Health together with the government to diversify health education on health issues in all public health facilities and communities so as to emphasis more on health issues, put guidelines for all the public health workers on following the laws and regulations regarding tobacco to ensure compliance and reduction of illegal tobacco and tobacco products to the country. In addition, ban all advertisements on tobacco products through media such newspapers, radios, televisions and billboards to reduce its use to the youths and young adults.

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