Introduction and Background- Immunization is the process whereby a person is made immune or resistant to an infectious disease, typically by the administration of a vaccine (WHO, April 2014). Globally immunization coverage as measured by proportion of children who have received DPT3 has been increasing from 74% in 2007 to 85% in 2010. It should be noted that the high immunization coverage should not be taken that all children have been immunized and yet so many children continue to miss their DPT3 in Africa (Mbabazi et al 2013). However the factors influencing the existing declining trend of immunisation coverage in Nwoya district are not well understood. The Main Objective- The study investigated the factors influencing immunisation coverage among children under 5 years in Nwoya district and suggested relevant recommendations for mitigation. Methods- A descriptive cross-sectional study was done by the researcher using both quantitative and qualitative method. The investigation was done among all health workers and community vaccinators in government health facility in Nwoya district. The data was collected using questionnaires to collect quantitative data from 162 health workers and community vaccinators in Nwoya district. Qualitative data was also collected using a Focus Group Discussion guide by conducting 6 FGDs of community leaders and VHTs in Nwoya district. The quantitative data was analyzed using SPSS, Epida 3.2 and Microsoft office excel and presented the findings in pie charts and tables. The qualitative data was manually analyzed and presented in quotations and verbatim. The research objectives were address through interpretation of quantitative and qualitative data according to the research objectives. The result- The finding from the study indicates that the major factors that specifically influence immunisation coverage among children under 5 in Nwoya district include the following: 6.2.1: Health workers factors The following health workers factors were found to have a significant influence on immunisation coverage among children under 5 years in Nwoya district are: level of qualification of the health workers (P-value<0.008),duration of qualification of the health workers(P-value<0.043),receiving of allowances for immunisation outreach activities(P-value<0.001 6.2.2: Health system factors The study also revealed the following health system factors that significantly influenced the immunisation coverage in Nwoya district: The number of outrearches per month(P-value<0.016), The availability of vaccines at health facility (P-value<0.001), and the availability of transport for immunisation activities (P-value<0.001 6.2.3 Community factors The key community factors that were found to have a significant influence on immunisation coverage was the level of mobilization of the community for immunisation (P-value<0.002).

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