Introduction: A brucella infection is among the most common human bacterial infections. They are distributed all over the world with high prevalence rates in tropical and sub-tropical countries mainly because human usually become infected by consuming unpasteurized milk or milk products from infected animals, inhaling it in dust on farms with infected animals or through direct contact with infected animals or surfaces. The main objective: This was to determine the prevalence of brucellosis among adult patients attending out patient department at Kidera health centre IV in Buyende District. Methods: The study was a descriptive cross sectional study employing both qualitative and quantitative methods of data collection. A total of 185 respondents were interviewed for quantitative data. The data collection tools where an interviewer administered questionnaires. A simple random sampling technique was used in the respondents. The data from the study was presented in form of frequency tables, figures and percentages. Results: About11.9 % of the 185 subjects were positive, 102 (55.1%) were females and 83 (44.9%) were males. 13 (12.7%) were females BAT positive and 9 (10.8%) of the men were BAT positive, of 136 participants who were animal keepers, 17(12.5%) were BAT positive and of the 47 who were not animal keepers 5(10.2%) were BAT positive. 18(25.4%) of the 71 participants who eat un boiled milk(bongo) were BAT positive, 4(3.6%) of the 110 participants who eat prepared animal products were BAT positive. And 4 of the participants who do not eat animal were BAT negative, of the 185 clients who participated in the study, 4(16.7%) of the 24 who were aged 16-30 were BAT positive. 8(9.6%) of the 83 participants who were aged 31-45 were BAT positive. 6(10.7%) of the 56 who were aged 46-60 were BAT positive and 2 (9.1%) of the 22 who were 61 years and above were BAT positive. Recommendation: The community members should continue to utilize village health teams to promote prevention measures like proper preparation of food before eating and ensuring health of domestic animals. The local groups such as churches, schools, women’s associations and others should be involved in promoting public health education efforts, teaching them about the signs and symptoms of brucellosis and ways to reduce the risk of the infection. The government should increase the funding to district laboratories and health center laboratories and all health facilities so as to improve on the diagnosis of brucellosis.

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